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(NEJM 2023), where retatrutide 12 mg produced 24.2% mean body-weight loss at 48 weeks without a plateau [1]

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Nutritional Deficiencies from Reduced Eating People eating very little on GLP-1 medications may become deficient in multiple nutrients required for collagen synthesis particularly vitamin C (a required cofactor for two collagen-synthesizing enzymes), zinc (required for collagen fiber stabilization), and copper (required for lysyl oxidase, which crosslinks collagen fibers)

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